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Inventi Impact: Med Chem

Articles

  • Inventi:pmc/18603/16
    QSAR Study of Petasin Derivatives as Antitumor Agents by Inhibiting SK-N-SH Cell Line
    15-Apr-2016 Research 2016 : April - June
    Thakur Rakeshranjan*, Vinay C Darji, Ronak N Patel, Kaushik Patel, Thakur Abhishek

    Petasin is a potential anticancer agent against human neuroblastoma cell SK-N-SH by inhibiting the extracellular signal-regulated protein kinases 1 and 2 phosphorylation. Due to great activity and new anti-proliferative mechanisms, QSAR study was done on a series of petasin derivatives. 14 compounds were used for QSAR against SK-N-SH cell line by using pIC50 activity. Here the QSAR studies of petasin derivatives were performed by using software CHEM-DRAW ULTRA-8.0, OPENBABLE- 2.2.1, DRAGON and VALSTAT. Two model equations for the QSAR study were considered.

    How to Cite this Article
    Thakur Rakeshranjan, Vinay C Darji, Ronak N Patel et al. QSAR Study of Petasin Derivatives as Antitumor Agents by Inhibiting SK-N-SH Cell Line. Inventi Impact: Med Chem, 2016(2):27-31, 2016.
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